Production of Tissue Factor Pathway Inhibitor in Cardiomyocytes and Its Upregulation by Interleukin-1

Overview

Journal Thromb Haemost

Publisher Thieme

Specialties Cardiology & Vascular Diseases
Hematology

Date 2002 Jan 31

PMID 11816723

Citations 4

Authors

A Kereveur

K Enjyoji

K Masuda

C Yutani

H Kato

Affiliations

Soon will be listed here.

Abstract

Tissue factor pathway inhibitor (TFPI) is a protease inhibitor that regulates tissue factor (TF)--initiated coagulation. We report here that cardiomyocytes express TFPI and the expression could be increased by Interleukin-1(IL-1beta). The TFPI expression in cardiomyocytes was confirmed by Northern blotting with rat cardiomyocytes and also by immunostaining with anti-TFPI antibody on human heart specimens from patients either with sarcoidosis, myocarditis or myocardial infarction. The regulation of TFPI expression in cardiomyocytes differs from that in endothelial cells because TFPI expression is not induced in human endothelial cells by IL-1beta.

Citing Articles

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets.

Daoud A, Lema D, Won T, cihakova D Front Cardiovasc Med. 2023; 10:1227818.

PMID: 37576111 PMC: 10419306. DOI: 10.3389/fcvm.2023.1227818.

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis.

Yang J, Jin K, Xiao J, Ma J, Ma D Front Med. 2017; 11(3):403-409.

PMID: 28550640 DOI: 10.1007/s11684-017-0522-y.

Tissue factor pathway inhibitor: structure-function.

Broze Jr G, Girard T Front Biosci (Landmark Ed). 2011; 17(1):262-80.

PMID: 22201743 PMC: 3692300. DOI: 10.2741/3926.

Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis.

White T, Johnson T, Zarzhevsky N, Tom C, Delacroix S, Holroyd E Blood. 2010; 116(10):1787-94.

PMID: 20516367 PMC: 2947398. DOI: 10.1182/blood-2009-10-250910.