The Spliceosome: No Assembly Required?

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2002 Jan 24

PMID 11804581

Citations 28

Authors

Timothy W Nilsen

Affiliations

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Abstract

In this issue of Molecular Cell, Stevens et al. purify a large particle from yeast extracts that contains all five of the U snRNPs required for pre-mRNA splicing. The existence of this "penta-snRNP" suggests the provocative possibility that spliceosome assembly does not depend upon a pre-mRNA substrate.

Citing Articles

Structural studies of the endogenous spliceosome - The supraspliceosome.

Sperling J, Sperling R Methods. 2017; 125:70-83.

PMID: 28412289 PMC: 5546952. DOI: 10.1016/j.ymeth.2017.04.005.

Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis.

Huang S, Zhang H, Yu B, McMahon E, Nguyen D, Yu F Mol Cell Biol. 2017; 37(9).

PMID: 28193846 PMC: 5394280. DOI: 10.1128/MCB.00446-16.

Transcription and Maturation of mRNA in Dinoflagellates.

Roy S, Morse D Microorganisms. 2016; 1(1):71-99.

PMID: 27694765 PMC: 5029490. DOI: 10.3390/microorganisms1010071.

The Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus.

Shefer K, Sperling J, Sperling R Comput Struct Biotechnol J. 2014; 11(19):113-22.

PMID: 25408845 PMC: 4232567. DOI: 10.1016/j.csbj.2014.09.008.

Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus.

Kotzer-Nevo H, de Lima Alves F, Rappsilber J, Sperling J, Sperling R Int J Mol Sci. 2014; 15(7):11637-64.

PMID: 24983480 PMC: 4139805. DOI: 10.3390/ijms150711637.