Cytotoxic Alkaloids from Houttuynia Cordata

Overview

Journal Arch Pharm Res

Specialty Pharmacology

Date 2002 Jan 17

PMID 11794526

Citations 20

Authors

S K Kim

S Y Ryu

J No

S U Choi

Y S Kim

Affiliations

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Abstract

Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

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