Systematic Identification of Novel Protein Domain Families Associated with Nuclear Functions

Overview

Journal Genome Res

Specialty Genetics

Date 2002 Jan 10

PMID 11779830

Citations 277

Authors

Tobias Doerks

Richard R Copley

Jorg Schultz

Chris P Ponting

Peer Bork

Affiliations

Soon will be listed here.

Abstract

A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

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