Familial Systemic Lupus Erythematosus: the Role of Genetic and Environmental Factors

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 2002 Jan 10

PMID 11779754

Citations 8

Authors

G E Eroglu

P F Kohler

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the contribution of genetic and environmental factors to disease occurrence in 26 families with two or more members affected with systemic lupus erythematosus (SLE).

Methods: Genetic and environmental factors were examined by HLA-A, B, C/DR typing and by determining the presence of lymphocytotoxic antibodies (LCA) in patients and their consanguineous and non-consanguineous relatives.

Results: No association between SLE and HLA-A, B, C antigens was found. There was, however, a significant association with HLA-DR2 in white subjects with SLE. The most striking finding was that HLA sharing was increased among the affected members, suggesting genetic similarities. Seven of 14 sib pairs (50%) who had concordant SLE were HLA identical as opposed to an expected 25%. Another interesting finding was that 15/18 (83%) patients with SLE and 11/22 (50%) consanguineous relatives had LCA, while 1/9 (11%) spouses, and 2/42 (5%) healthy controls had these antibodies.

Conclusion: Genetic factors have a role in the development and expression of SLE. Environmental factors may trigger the disease in genetically susceptible hosts.

Citing Articles

Chronic psychiatric illness masquerading as bipolar disorder in a family secondary to familial systemic lupus erythematosus with limbic encephalitis.

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T cell receptor sequencing in autoimmunity.

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Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway.

Xue Z, Cui C, Liao Z, Xia S, Zhang P, Qin J Front Immunol. 2019; 9:2967.

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Prevalence of Family History of Autoimmune Disorders in Juvenile Systemic Lupus Erythematosus.

Ashournia P, Sadeghi P, Rezaei N, Moradinejad M, Ziaee V Maedica (Bucur). 2018; 13(1):21-24.

PMID: 29868136 PMC: 5972782.

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