Gene Therapy for Liver Diseases: Recent Strategies for Treatment of Viral Hepatitis and Liver Malignancies

Overview

Journal Gut

Specialty Gastroenterology

Date 2002 Jan 5

PMID 11772981

Citations 12

Authors

V Schmitz

C Qian

J Ruiz

B Sangro

I Melero

G Mazzolini

I Narvaiza

J Prieto

Affiliations

Soon will be listed here.

Abstract

Gene therapy has emerged as a powerful and very plastic tool to regulate biological functions in diseased tissues with application in virtually all medical fields. An increasing number of experimental and clinical studies underline the importance of genes as curative agents in the future. However, intense research is needed to evaluate the potential of gene therapy to improve efficacy and minimise the toxicity of the procedure.

Citing Articles

Gene therapy for people with hepatocellular carcinoma.

Naing C, Ni H, Aung H, Htet N, Nikolova D Cochrane Database Syst Rev. 2024; 6:CD013731.

PMID: 38837373 PMC: 11152182. DOI: 10.1002/14651858.CD013731.pub2.

Leveraging stem cells to combat hepatitis: a comprehensive review of recent studies.

Raoufinia R, Arabnezhad A, Keyhanvar N, Abdyazdani N, Saburi E, Naseri N Mol Biol Rep. 2024; 51(1):459.

PMID: 38551743 DOI: 10.1007/s11033-024-09391-y.

HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1‑pAFP-TK and targeted killing effect.

Li Y, Yuan Y, Zhang Y, Zhao N, Zhang Q, Meng F Mol Med Rep. 2017; 16(1):764-772.

PMID: 28560395 PMC: 5482189. DOI: 10.3892/mmr.2017.6657.

Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees.

Verstrepen B, Boonstra A, Koopman G World J Hepatol. 2015; 7(1):53-69.

PMID: 25624997 PMC: 4295194. DOI: 10.4254/wjh.v7.i1.53.

Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.

Wang G, Dong X, Tian W, Lu Y, Hu J, Liu Y Chin J Cancer Res. 2014; 25(6):646-55.

PMID: 24385691 PMC: 3872543. DOI: 10.3978/j.issn.1000-9604.2013.11.07.

References

Aurisicchio L, DELMASTRO P, Salucci V, Paz O, Rovere P, Ciliberto G . Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis. J Virol. 2000; 74(10):4816-23. PMC: 112004. DOI: 10.1128/jvi.74.10.4816-4823.2000. View

Moolten F . Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Ther. 1994; 1(4):279-87. View

Prince H . Gene transfer: a review of methods and applications. Pathology. 1998; 30(4):335-47. DOI: 10.1080/00313029800169606. View

Heideman D, Gerritsen W, Craanen M . Gene therapy for gastrointestinal tract cancer: a review. Scand J Gastroenterol Suppl. 2001; (232):93-100. View

Kafri T, Blomer U, Peterson D, Gage F, Verma I . Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet. 1997; 17(3):314-7. DOI: 10.1038/ng1197-314. View

Saeki Y, Matsumoto N, Nakano Y, Mori M, Awai K, Kaneda Y . Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Hum Gene Ther. 1997; 8(17):2133-41. DOI: 10.1089/hum.1997.8.17-2133. View

Miller A . Human gene therapy comes of age. Nature. 1992; 357(6378):455-60. DOI: 10.1038/357455a0. View

Tang D, DeVit M, Johnston S . Genetic immunization is a simple method for eliciting an immune response. Nature. 1992; 356(6365):152-4. DOI: 10.1038/356152a0. View

Bruna-Romero O, Lasarte J, Wilkinson G, Grace K, Clarke B, Borras-Cuesta F . Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus. Hepatology. 1997; 25(2):470-7. DOI: 10.1002/hep.510250236. View

10.

Grossman M, Raper S, Kozarsky K, Stein E, Engelhardt J, Muller D . Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet. 1994; 6(4):335-41. DOI: 10.1038/ng0494-335. View

11.

Drozdzik M, Qian C, Xie X, Peng D, Bilbao R, Mazzolini G . Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma. J Hepatol. 2000; 32(2):279-86. DOI: 10.1016/s0168-8278(00)80073-2. View

12.

Kuriyama S, Nakatani T, Masui K, Sakamoto T, Tominaga K, Yoshikawa M . Evaluation of prodrugs ability to induce effective ablation of cells transduced with viral thymidine kinase gene. Anticancer Res. 1996; 16(5A):2623-8. View

13.

Lai E, Fan S, Lo C, Chu K, Liu C, Wong J . Hepatic resection for hepatocellular carcinoma. An audit of 343 patients. Ann Surg. 1995; 221(3):291-8. PMC: 1234572. DOI: 10.1097/00000658-199503000-00012. View

14.

Miyanohara A, Johnson P, Elam R, Dai Y, Witztum J, Verma I . Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. New Biol. 1992; 4(3):238-46. View

15.

Yang Y, Nunes F, Berencsi K, Furth E, Gonczol E, Wilson J . Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci U S A. 1994; 91(10):4407-11. PMC: 43794. DOI: 10.1073/pnas.91.10.4407. View

16.

Hayashi S, Emi N, Yokoyama I, Namii Y, Uchida K, Takagi H . Inhibition of establishment of hepatic metastasis in mice by combination gene therapy using both herpes simplex virus-thymidine kinase and granulocyte macrophage-colony stimulating factor genes in murine colon cancer. Cancer Gene Ther. 1997; 4(6):339-44. View

17.

Holmberg E, Reuer Q, Geisert E, Owens J . Delivery of plasmid DNA to glial cells using pH-sensitive immunoliposomes. Biochem Biophys Res Commun. 1994; 201(2):888-93. DOI: 10.1006/bbrc.1994.1785. View

18.

Colombo M, Forni G . Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?. Immunol Today. 1994; 15(2):48-51. DOI: 10.1016/0167-5699(94)90131-7. View

19.

Mulligan R . The basic science of gene therapy. Science. 1993; 260(5110):926-32. DOI: 10.1126/science.8493530. View

20.

Mazzolini G, Qian C, Narvaiza I, Barajas M, Borras-Cuesta F, Xie X . Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level. Hum Gene Ther. 2000; 11(1):113-25. DOI: 10.1089/10430340050016201. View