Infantile Sialidosis: a Phenocopy of Type 1 GM1 Gangliosidosis Distinguished by Genetic Complementation and Urinary Oligosaccharides

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1979 Nov 1

PMID 117700

Citations 11

Authors

R A Gravel

J A Lowden

J W Callahan

L S Wolfe

N M Ng Yin Kin

Affiliations

Soon will be listed here.

Abstract

A clinical description of an apparently classical case of type 1 GM1 gangliosidosis is presented. The patient was the first-born child of first cousins. She was diagnosed at 6 weeks and died at 6 months. beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates. Genetic complementation studies performed after cell fusion between cultured fibroblasts from the patient and from two other type 1, one type 2, and one juvenile GM1 gangliosidosis strain were positive with all strains. Subsequent studies revealed an increased excretion of a sialic acid-containing hexasaccharide in the patient's cells. Parents' fibroblasts contained normal levels of beta-galactosidase. The case emphasizes the variability of the clinical expression in sialidosis and the importance of demonstrating a primary gene defect in establishing a diagnosis of an inborn error or metabolism.

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