Evaluation by Contrast-enhanced MR Imaging of the Lateral Border Zone in Reperfused Myocardial Infarction in a Cat Model

Overview

Journal Korean J Radiol

Specialty Radiology

Date 2001 Dec 26

PMID 11752965

Citations 4

Authors

A K Jeong

S I Choi

D H Kim

S B Park

S S Lee

S H Choi

T H Lim

Affiliations

Soon will be listed here.

Abstract

Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model.

Materials And Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. ECG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted MR images were obtained for three hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructural changes in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed.

Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area on Gadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTC staining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage.

Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

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References

Ni Y, Marchal G, Herijgers P, Flameng W, Petre C, Ebert W . Paramagnetic metalloporphyrins: from enhancers of malignant tumors to markers of myocardial infarcts. Acad Radiol. 1996; 3 Suppl 2:S395-7. DOI: 10.1016/s1076-6332(96)80595-2. View

Marchal G, Ni Y, Herijgers P, Flameng W, Petre C, Bosmans H . Paramagnetic metalloporphyrins: infarct avid contrast agents for diagnosis of acute myocardial infarction by MRI. Eur Radiol. 1996; 6(1):2-8. DOI: 10.1007/BF00619942. View

Braunwald E . Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction, and improved survival. Should the paradigm be expanded?. Circulation. 1989; 79(2):441-4. DOI: 10.1161/01.cir.79.2.441. View

Factor S, Okun E, Kirk E . The histological lateral border of acute canine myocardial infarction. A function of microcirculation. Circ Res. 1981; 48(5):640-49. DOI: 10.1161/01.res.48.5.640. View

Muller R, Vander Elst L, Colet J, Herrent P, Seghi F, Pamart L . Spectroscopic monitoring of the cellular internalization of paramagnetic ions and their complexes: a perifused cells and perfused organs approach. Acad Radiol. 1996; 3 Suppl 2:S277-81. DOI: 10.1016/s1076-6332(96)80556-3. View

Jennings R, Reimer K . Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood. Circulation. 1983; 68(2 Pt 2):I25-36. View

Hindre F, Le Plouzennec M, de Certaines J, Foultier M, Patrice T, Simonneaux G . Tetra-p-aminophenylporphyrin conjugated with Gd-DTPA: tumor-specific contrast agent for MR imaging. J Magn Reson Imaging. 1993; 3(1):59-65. DOI: 10.1002/jmri.1880030111. View

Yellon D, Hearse D, Crome R, Grannell J, Wyse R . Characterization of the lateral interface between normal and ischemic tissue in the canine heart during evolving myocardial infarction. Am J Cardiol. 1981; 47(6):1233-9. DOI: 10.1016/0002-9149(81)90252-6. View

de Roos A, Matheijssen N, Doornbos J, van Dijkman P, VAN VOORTHUISEN A, van der Wall E . Myocardial infarct size after reperfusion therapy: assessment with Gd-DTPA-enhanced MR imaging. Radiology. 1990; 176(2):517-21. DOI: 10.1148/radiology.176.2.2367668. View

10.

Rivas F, COBB F, BACHE R, GREENFIELD Jr J . Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs. Circ Res. 1976; 38(5):439-47. DOI: 10.1161/01.res.38.5.439. View

11.

Judd R, Arai M, Kondo T, Croisille P, Lima J, Mohan V . Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation. 1995; 92(7):1902-10. DOI: 10.1161/01.cir.92.7.1902. View

12.

Whitman G, Kieval R, Wetstein L, Seeholzer S, McDonald G, Harken A . The relationship between global myocardial ischemia, left ventricular function, myocardial redox state, and high energy phosphate profile. A phosphorous-31 nuclear magnetic resonance study. J Surg Res. 1983; 35(4):332-9. DOI: 10.1016/0022-4804(83)90009-4. View

13.

Maxwell S, Lip G . Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol. 1997; 58(2):95-117. DOI: 10.1016/s0167-5273(96)02854-9. View

14.

Johnston D, Thompson R, Liu P, Dinsmore R, Wismer G, Saini S . Magnetic resonance imaging during acute myocardial infarction. Am J Cardiol. 1986; 57(13):1059-65. DOI: 10.1016/0002-9149(86)90674-0. View

15.

Weinmann H, Brasch R, Press W, Wesbey G . Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. AJR Am J Roentgenol. 1984; 142(3):619-24. DOI: 10.2214/ajr.142.3.619. View

16.

Saeed M, Wendland M, Masui T, Higgins C . Reperfused myocardial infarctions on T1- and susceptibility-enhanced MRI: evidence for loss of compartmentalization of contrast media. Magn Reson Med. 1994; 31(1):31-9. DOI: 10.1002/mrm.1910310105. View

17.

Jugdutt B, Hutchins G, Bulkley B, Pitt B, Becker L . Effect of indomethacin on collateral blood flow and infarct size in the conscious dog. Circulation. 1979; 59(4):734-43. DOI: 10.1161/01.cir.59.4.734. View

18.

Reimer K, Lowe J, Rasmussen M, Jennings R . The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977; 56(5):786-94. DOI: 10.1161/01.cir.56.5.786. View

19.

Young S, Sidhu M, Qing F, Muller H, Neuder M, Zanassi G . Preclinical evaluation of gadolinium (III) texaphyrin complex. A new paramagnetic contrast agent for magnetic resonance imaging. Invest Radiol. 1994; 29(3):330-8. DOI: 10.1097/00004424-199403000-00013. View

20.

Lim T, Hong M, Lee J, Mun C, Park S, Park S . Novel application of breath-hold turbo spin-echo T2 MRI for detection of acute myocardial infarction. J Magn Reson Imaging. 1997; 7(6):996-1001. DOI: 10.1002/jmri.1880070611. View