Slit: a Roadblock for Chemotaxis

Overview

Journal Sci STKE

Specialties Cell Biology
Physiology
Science

Date 2001 Dec 26

PMID 11752663

Citations 8

Authors

A Z Fernandis

R K Ganju

Affiliations

Soon will be listed here.

Abstract

The immune system and nervous system display striking similarities. Fernandis and Ganju discuss yet another example where a protein (Slit) originally identified for its role in modulating axon pathfinding is able to regulate immune cell migration. Slit isoforms expressed in the nervous system interact with members of the Robo receptor family to modify movement stimulated by the secreted attractants netrins and their receptors. In leukocytes, Slit 2 interacting with Robo receptors inhibits movement stimulated by the chemokine receptor (CXCR4). Fernandis and Ganju discuss the therapeutic potential of Slit as an antiviral agent and in the treatment of inflammatory diseases, autoimmune disorders, and cancer.

Citing Articles

Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.

Qi C, Lan H, Ye J, Li W, Wei P, Yang Y Lab Invest. 2014; 94(7):766-76.

PMID: 24840330 DOI: 10.1038/labinvest.2014.70.

Transcriptome profiling of granulosa cells of bovine ovarian follicles during growth from small to large antral sizes.

Hatzirodos N, Irving-Rodgers H, Hummitzsch K, Harland M, Morris S, Rodgers R BMC Genomics. 2014; 15:24.

PMID: 24422759 PMC: 3898003. DOI: 10.1186/1471-2164-15-24.

Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia.

Zhao H, Anand A, Ganju R J Immunol. 2013; 192(1):385-93.

PMID: 24272999 PMC: 3908786. DOI: 10.4049/jimmunol.1302021.

Genome-wide association study of antibody response to Newcastle disease virus in chicken.

Luo C, Qu H, Ma J, Wang J, Li C, Yang C BMC Genet. 2013; 14:42.

PMID: 23663563 PMC: 3654938. DOI: 10.1186/1471-2156-14-42.

Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium.

Brantley-Sieders D, Dunaway C, Rao M, Short S, Hwang Y, Gao Y Cancer Res. 2010; 71(3):976-87.

PMID: 21148069 PMC: 3032824. DOI: 10.1158/0008-5472.CAN-10-3396.