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Deformation and Fragmentation of Human Red Blood Cells in Turbulent Shear Flow

Overview
Journal Biophys J
Publisher Cell Press
Specialty Biophysics
Date 1975 Jan 1
PMID 1174639
Citations 31
Authors
S P Sutera
M H Mehrjardi
Affiliations
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Abstract

By means of glutaraldehyde fixation, human erythrocytes are "frozen" while suspended in turbulent shear flow. As the shearing is increased in steps from 100 to 2,500 dyn/cm2, the deformed cells evolve gradually toward a smooth ellipsoidal shape. At stresses above 2,500 dyn/cm2, approximately, fragmentation of the cells occurs with a concomitant increase in free hemoglobin content of the suspending medium. The photographic evidence suggests that the cells rupture in tension in the bulk flow.

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