Chorioallantoic Membrane Capillary Bed: a Useful Target for Studying Angiogenesis and Anti-angiogenesis in Vivo

Overview

Journal Anat Rec

Specialty Anatomy & Histology

Date 2001 Dec 18

PMID 11745087

Citations 69

Authors

D Ribatti

B Nico

A Vacca

L Roncali

P H Burri

V Djonov

Affiliations

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Abstract

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti-angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the existence of a single blood sinus or a capillary plexus underlying the chorionic epithelium; 3) describes a new model of the CAM vascular growth, namely the intussusceptive mode; 4) reports findings regarding the role played by endogenous fibroblast growth factor-2 in CAM vascularization; and 5) addresses the use and limitations of the CAM as a model for studying angiogenesis and anti-angiogenesis.

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