Alternative Splicing and Genome Complexity

Overview

Journal Nat Genet

Specialty Genetics

Date 2001 Dec 18

PMID 11743582

Citations 190

Authors

David Brett

Heike Pospisil

Juan Valcarcel

Jens Reich

Peer Bork

Affiliations

Soon will be listed here.

Abstract

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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