C-16 Artemisinin Derivatives and Their Antimalarial and Cytotoxic Activities: Syntheses of Artemisinin Monomers, Dimers, Trimers, and Tetramers by Nucleophilic Additions to Artemisitene

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2001 Dec 14

PMID 11741486

Citations 6

Authors

S Ekthawatchai

S Kamchonwongpaisan

P Kongsaeree

B Tarnchompoo

Y Thebtaranonth

Y Yuthavong

Affiliations

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Abstract

Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grignard reagents to artemisitene provided C-16-derived artemisinin monomers, dimers, trimers, and tetramers whose antimalarial and cytotoxic activities have been evaluated.

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