First Generation Design, Synthesis, and Evaluation of Azepine-based Cryptophycin Analogues

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2001 Dec 12

PMID 11735585

Citations 4

Authors

A B Smith 3rd

Y S Cho

L E Zawacki

R Hirschmann

G R Pettit

Affiliations

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Abstract

[structure: see text] Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.

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