Ketone-DNA: a Versatile Postsynthetic DNA Decoration Platform

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2001 Dec 12

PMID 11735565

Citations 4

Authors

S Dey

T L Sheppard

Affiliations

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Abstract

[reaction: see text] A general strategy for the functional diversification of DNA oligonucleotides under physiological conditions was developed. We describe the synthesis of DNA molecules bearing ketone ports (ketone-DNA) and the efficient postsynthetic decoration of ketone-DNA with structurally diverse aminooxy compounds.

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