Mechanisms Underlying Rapid Experience-dependent Plasticity in the Human Visual Cortex

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Dec 6

PMID 11734655

Citations 31

Authors

B Boroojerdi

F Battaglia

W Muellbacher

L G Cohen

Affiliations

Soon will be listed here.

Abstract

Visual deprivation induces a rapid increase in visual cortex excitability that may result in better consolidation of spatial memory in animals and in lower visual recognition thresholds in humans. gamma-Aminobutyric acid (GABA)ergic, N-methyl-d-aspartate (NMDA), and cholinergic receptors are thought to be involved in visual cortex plasticity in animal studies. Here, we used a pharmacological approach and found that lorazepam (which enhances GABA(A) receptor function by acting as a positive allosteric modulator), dextrometorphan (NMDA receptor antagonist), and scopolamine (muscarinic receptor antagonist) blocked rapid plastic changes associated with light deprivation. These findings suggest the involvement of GABA, NMDA, and cholinergic receptors in rapid experience-dependent plasticity in the human visual cortex.

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References

AMASSIAN V, Cracco R, Maccabee P, Cracco J, Rudell A, Eberle L . Transcranial magnetic stimulation in study of the visual pathway. J Clin Neurophysiol. 1998; 15(4):288-304. DOI: 10.1097/00004691-199807000-00002. View

Ziemann U, Hallett M, Cohen L . Mechanisms of deafferentation-induced plasticity in human motor cortex. J Neurosci. 1998; 18(17):7000-7. PMC: 6792971. View

Roberts E, Meredith M, Ramoa A . Suppression of NMDA receptor function using antisense DNA block ocular dominance plasticity while preserving visual responses. J Neurophysiol. 1998; 80(3):1021-32. DOI: 10.1152/jn.1998.80.3.1021. View

Kammer T . Phosphenes and transient scotomas induced by magnetic stimulation of the occipital lobe: their topographic relationship. Neuropsychologia. 1999; 37(2):191-8. DOI: 10.1016/s0028-3932(98)00093-1. View

Quinlan E, Philpot B, Huganir R, Bear M . Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat Neurosci. 1999; 2(4):352-7. DOI: 10.1038/7263. View

Calabresi P, Centonze D, Gubellini P, Bernardi G . Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP. Neuropharmacology. 1999; 38(2):323-6. DOI: 10.1016/s0028-3908(98)00199-3. View

Butefisch C, Davis B, Wise S, Sawaki L, Kopylev L, Classen J . Mechanisms of use-dependent plasticity in the human motor cortex. Proc Natl Acad Sci U S A. 2000; 97(7):3661-5. PMC: 16296. DOI: 10.1073/pnas.97.7.3661. View

Boroojerdi B, Bushara K, Corwell B, Immisch I, Battaglia F, Muellbacher W . Enhanced excitability of the human visual cortex induced by short-term light deprivation. Cereb Cortex. 2000; 10(5):529-34. DOI: 10.1093/cercor/10.5.529. View

Cowey A, Walsh V . Magnetically induced phosphenes in sighted, blind and blindsighted observers. Neuroreport. 2000; 11(14):3269-73. DOI: 10.1097/00001756-200009280-00044. View

10.

Hendry S, Jones E . Activity-dependent regulation of GABA expression in the visual cortex of adult monkeys. Neuron. 1988; 1(8):701-12. DOI: 10.1016/0896-6273(88)90169-9. View

11.

Nachum Z, Shahal B, Shupak A, Spitzer O, Gonen A, Beiran I . Scopolamine bioavailability in combined oral and transdermal delivery. J Pharmacol Exp Ther. 2000; 296(1):121-3. View

12.

Wiesel T, Hubel D . Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J Neurophysiol. 1965; 28(6):1029-40. DOI: 10.1152/jn.1965.28.6.1029. View

13.

LACIGA Z . [Proposal of an examination outline using electrodes with the system "10-20"]. Cesk Neurol. 1968; 31(4):236-8. View

14.

Worsham R, DAmato M . Ambient light, white noise, and monkey vocalization as sources of interference in visual short-term memory of monkeys. J Exp Psychol. 1973; 99(1):99-105. DOI: 10.1037/h0034770. View

15.

Suedfeld P . The benefits of boredom: sensory deprivation reconsidered. Am Sci. 1975; 63(1):60-9. View

16.

Grimm V, Samuel D . The effects of dark isolation on the performance of a white-black discrimination task in the rat. Int J Neurosci. 1976; 7(1):1-7. DOI: 10.3109/00207457609147193. View

17.

Artola A, Singer W . Long-term potentiation and NMDA receptors in rat visual cortex. Nature. 1987; 330(6149):649-52. DOI: 10.1038/330649a0. View

18.

Sanes J, Suner S, Lando J, Donoghue J . Rapid reorganization of adult rat motor cortex somatic representation patterns after motor nerve injury. Proc Natl Acad Sci U S A. 1988; 85(6):2003-7. PMC: 279910. DOI: 10.1073/pnas.85.6.2003. View

19.

Metherate R, Tremblay N, Dykes R . Transient and prolonged effects of acetylcholine on responsiveness of cat somatosensory cortical neurons. J Neurophysiol. 1988; 59(4):1253-76. DOI: 10.1152/jn.1988.59.4.1253. View

20.

Wong B, Coulter D, Choi D, Prince D . Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices. Neurosci Lett. 1988; 85(2):261-6. DOI: 10.1016/0304-3940(88)90362-x. View