The Hypercalcaemic Syndrome in Rats Bearing the Walker Carcinosarcoma 256

Overview

Journal Acta Endocrinol (Copenh)

Specialty Endocrinology

Date 1975 Mar 1

PMID 1173020

Citations 15

Authors

H Minne

F Raue

S Bellwinkel

R Ziegler

Affiliations

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Abstract

The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium. These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.

Citing Articles

Osteoporosis-like changes in Walker carcinoma 256-bearing rats, not accompanied with hypercalcemia or parathyroid hormone-related protein production.

Waki Y, Miyamoto K, Kasugai S, Ohya K Jpn J Cancer Res. 1995; 86(5):470-6.

PMID: 7540609 PMC: 5920849. DOI: 10.1111/j.1349-7006.1995.tb03080.x.

Prostaglandin E production and hypercalcaemia in rats bearing the Walker carcinosarcoma.

Seyberth H, Bonsch G, Muller H, Minne H, Erlenmaier T, Strein K Br J Cancer. 1980; 42(3):455-61.

PMID: 7426347 PMC: 2010425. DOI: 10.1038/bjc.1980.258.

Partial characterization of a bone-derived chemotactic factor for tumor cells.

Orr F, Varani J, Gondek M, Ward P, Mundy G Am J Pathol. 1980; 99(1):43-52.

PMID: 7361862 PMC: 1903471.

Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.

Rodan S, Insogna K, Vignery A, Stewart A, Broadus A, Dsouza S J Clin Invest. 1983; 72(4):1511-5.

PMID: 6685137 PMC: 370436. DOI: 10.1172/JCI111108.

Different effects of hypercalcemic state induced by Walker tumor (HWCS 256) and 1,25 (OH)D3 intoxication on rat thyroid C cells. An ultrastructural, immunocytochemical, and biochemical study.

Rix E, Raue F, Deutschle I, Ziegler R Histochemistry. 1984; 80(5):503-8.

PMID: 6548209 DOI: 10.1007/BF00495442.