Epidemiology and Prevention of Invasive Aspergillosis

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2001 Nov 28

PMID 11722807

Citations 5

Authors

David W Warnock

Rana A Hajjeh

Brent A Lasker

Affiliations

Soon will be listed here.

Abstract

Aspergillus species are the most common causes of invasive mold infections in immunocompromised persons. This review examines the available information regarding the rising incidence of invasive aspergillosis in different high-risk groups, including persons with acute leukemia, hematopoietic stem cell transplant recipients, and liver and lung transplant recipients. The risk factors for infection in these groups are discussed. Because Aspergillus species are widespread in the environment, it is difficult to link specific sources and exposures to the development of human infections. However, molecular strain typing and other studies indicate that a significant number of Aspergillus infections are now being acquired outside the health care setting, either before patients are admitted to hospital, or after they have been discharged. The role of environmental control measures and antifungal drug prophylaxis in the prevention of hospital- and community-acquired aspergillosis is discussed.

Citing Articles

Distribution of species and risk factors for aspergillosis in mainland China: a systematic review.

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Aspergillus infection in chronic obstructive pulmonary diseases.

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Posaconazole-Loaded Leukocytes as a Novel Treatment Strategy Targeting Invasive Pulmonary Aspergillosis.

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Aspergillus ustus infections among transplant recipients.

Panackal A, Imhof A, Hanley E, Marr K Emerg Infect Dis. 2006; 12(3):403-8.

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Assessment of ribosomal large-subunit D1-D2, internal transcribed spacer 1, and internal transcribed spacer 2 regions as targets for molecular identification of medically important Aspergillus species.

Hinrikson H, Hurst S, Lott T, Warnock D, Morrison C J Clin Microbiol. 2005; 43(5):2092-103.

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