Determination of Benzene and Toluene in Blood by Means of a Syringe-equilibration Method Using a Small Amount of Blood

Overview

Journal Br J Ind Med

Specialty Occupational Medicine

Date 1975 Aug 1

PMID 1171695

Citations 17

Authors

A Sato

T Nakajima

Y Fujiwara

Affiliations

Soon will be listed here.

Abstract

A gas chromatographic determination of benzene and toluene in blood with a small amount of blood sample, 0.02 or 0.1 ml, is described. In the method an aliquot of the blood sample in a sealed hypodermic syringe of 2 ml capacity is equilibrated at 37 degrees C in a thermo-regulated water-bath. After establishing equilibrium 1 ml of overlying air is submitted to gas chromatographic analysis. The value of this method was verified by experiments in which men, rabbits, and rats were exposed to benzene and toluene mixtures of various concentrations.

Citing Articles

Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. II. 1,1,1-Trichloroethane and trichloroethylene.

Lapare S, Tardif R, Brodeur J Int Arch Occup Environ Health. 1995; 67(6):375-94.

PMID: 8567088 DOI: 10.1007/BF00381051.

Acute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans.

Kishi R, Harabuchi I, Ikeda T, Katakura Y, Miyake H Br J Ind Med. 1993; 50(5):470-80.

PMID: 8507600 PMC: 1012166. DOI: 10.1136/oem.50.5.470.

Circadian variations of acute toxicity and blood and brain concentrations of inhaled toluene in rats.

Harabuchi I, Kishi R, Ikeda T, Kiyosawa H, Miyake H Br J Ind Med. 1993; 50(3):280-6.

PMID: 8457497 PMC: 1061277. DOI: 10.1136/oem.50.3.280.

Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. I. Toluene and m-xylene.

Lapare S, Tardif R, Brodeur J Int Arch Occup Environ Health. 1993; 64(8):569-80.

PMID: 8314616 DOI: 10.1007/BF00517703.

Enzyme induction by ethanol consumption affects the pharmacokinetics of inhaled m-xylene only at high levels of exposure.

Kaneko T, Wang P, Sato A Arch Toxicol. 1993; 67(7):473-7.

PMID: 8239996 DOI: 10.1007/BF01969918.

References

Lowe H . FLAME IONIZATION DETECTION OF VOLATILE ORGANIC ANESTHETICS IN BLOOD, GASES AND TISSUES. Anesthesiology. 1964; 25:808-14. DOI: 10.1097/00000542-196411000-00012. View

Cousins M, MAZZE R . A rapid direct-injection method for measuring volatile anesthetics in whole blood. Anesthesiology. 1972; 36(3):293-6. DOI: 10.1097/00000542-197203000-00019. View

Levy G, Gibaldi M . Pharmacokinetics of drug action. Annu Rev Pharmacol. 1972; 12:85-98. DOI: 10.1146/annurev.pa.12.040172.000505. View

Jones P, Molloy M, Rosen M . A technique for the analysis of methoxyflurane in blood by gas chromatography. Br J Anaesth. 1972; 44(2):124-30. DOI: 10.1093/bja/44.2.124. View

Szadkowski D, Schroter U, Essing H, Schaller K, Lehnert G . [Gaschromatographic determination of benzene and toluene in small amounts of blood]. Int Arch Arbeitsmed. 1971; 27(4):300-8. View