Signalling Pathways in Drosophila and Vertebrate Retinal Development

The near-catholic conservation of paired box gene 6 (Pax6) and its supporting cast of retinal determination genes throughout the animal kingdom has sparked a scientific war over the evolutionary origins of the eye. The battle pits those who support a polyphyletic history for the eye against those who argue for a common ancestor for all 'seeing' animals. Recent papers have shed light on how eyes in both vertebrates and invertebrates are patterned. New insights into the roles that signal-transduction cascades might have in determining the Drosophila melanogaster eye indicate that, like many developmental processes, eye specification is an inductive process.