Polysubstance Abuse-vulnerability Genes: Genome Scans for Association, Using 1,004 Subjects and 1,494 Single-nucleotide Polymorphisms

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2001 Nov 13

PMID 11704927

Citations 94

Authors

G R Uhl

Q R Liu

D Walther

J Hess

D Naiman

Affiliations

Soon will be listed here.

Abstract

Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.

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