Inhibition of Isoprenoid Biosynthesis Causes Insulin Resistance in 3T3-L1 Adipocytes

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2001 Nov 7

PMID 11696371

Citations 43

Authors

L H Chamberlain

Affiliations

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Abstract

Lovastatin treatment caused down-regulation of the insulin-responsive glucose transporter 4 (Glut4) and up-regulation of Glut1 in 3T3-L1 adipocytes. These changes in protein expression were associated with a marked inhibition of insulin-stimulated glucose transport. Lovastatin had no effect on cell cholesterol levels, but its effects were reversed by mevalonate, demonstrating that inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. These findings support the notion that whole body insulin resistance may arise as a result of perturbations in general biochemical pathways, rather than primary defects in insulin signalling.

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