Altered Performance on an Ocular Fixation Task in Attention-deficit/hyperactivity Disorder

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2001 Nov 3

PMID 11690600

Citations 20

Authors

T D Gould

T M Bastain

M E Israel

D W Hommer

F X Castellanos

Affiliations

Soon will be listed here.

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder without validated objective markers. Eye movement studies may be useful in providing objective criteria for characterizing the disorder.

Methods: We compared 53 children (29 girls) with ADHD to 44 healthy control children (18 girls) on a 21-sec fixation task. Large saccades (> 4 degrees ) away from the fixation point were analyzed.

Results: Children with ADHD made more large saccades that interrupted fixation than did control children (p =.001). Mean scores of the ADHD group did not change significantly with subsequent retesting on placebo (p =.11); however, there was poor intrasubject correlation (r =.16).

Conclusions: Both boys and girls with ADHD made significantly more intrusive saccades during fixation than did control subjects, possibly reflecting intrinsic neurologic dysfunction; however, a probable "floor effect" obviates conclusions about the reliability of this measure.

Citing Articles

Effects of Auditory and Visual White Noise on Oculomotor Inhibition in Children With Attention-Deficit/Hyperactivity Disorder: Protocol for a Crossover Study.

Jostrup E, Nystrom M, Tallberg P, Soderlund G, Gustafsson P, Claesdotter-Knutsson E JMIR Res Protoc. 2024; 13:e56388.

PMID: 39146010 PMC: 11362705. DOI: 10.2196/56388.

Age-Based Developmental Biomarkers in Eye Movements: A Retrospective Analysis Using Machine Learning.

Hunfalvay M, Bolte T, Singh A, Greenstein E, Murray N, Carrick F Brain Sci. 2024; 14(7).

PMID: 39061426 PMC: 11274786. DOI: 10.3390/brainsci14070686.

Motor synchronization and impulsivity in pediatric borderline personality disorder with and without attention-deficit hyperactivity disorder: an eye-tracking study of saccade, blink and pupil behavior.

Calancie O, Parr A, Brien D, Huang J, Pitigoi I, Coe B Front Neurosci. 2023; 17:1179765.

PMID: 37425020 PMC: 10323365. DOI: 10.3389/fnins.2023.1179765.

Comparison of LSTM, Transformers, and MLP-mixer neural networks for gaze based human intention prediction.

Pettersson J, Falkman P Front Neurorobot. 2023; 17:1157957.

PMID: 37304663 PMC: 10248176. DOI: 10.3389/fnbot.2023.1157957.

Effects of word length and word frequency among dyslexic, ADHD-I and typical readers.

Pereira N, Costa M, Guerreiro M J Eye Mov Res. 2023; 15(1).

PMID: 37009492 PMC: 10063363. DOI: 10.16910/jemr.15.1.1.