Reprogramming of Genome Function Through Epigenetic Inheritance

Overview

Journal Nature

Specialty Science

Date 2001 Nov 2

PMID 11689958

Citations 91

Authors

M A Surani

Affiliations

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Abstract

Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.

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