Identification of Six Putative Novel Human Papillomaviruses (HPV) and Characterization of Candidate HPV Type 87

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2001 Nov 2

PMID 11689676

Citations 6

Authors

S Menzo

A Monachetti

C Trozzi

A Ciavattini

G Carloni

P E Varaldo

M Clementi

Affiliations

Soon will be listed here.

Abstract

Six putative novel human papillomavirus (HPV) types were detected by using general primers for a conserved L1 HPV region in patients examined in gynecologic centers. One of the isolates, detected in samples from 4 patients with koilocytic atypia at cervical cytology (3 of whom were also infected with human immunodeficiency virus type 1), was completely sequenced, identified as a new HPV genotype, and designated candidate HPV87 (candHPV87) by the Reference Center for Human Papillomavirus. candHPV87 shows the classic HPV genome organization and the absence of a functional E5 coding region. Phylogenetic analysis documented that the candHPV87 genome clusters within the A3 group of HPVs, together with HPV61, HPV72, HPV83, HPV84 and candHPV86, which have been completely sequenced, and a number of other putative novel genotypes (two of which are described in this work), which have been partially characterized. To address the growth-enhancing potential of candHPV87, the E6 and E7 putative coding regions were cloned and expressed in tissue cultures. The data indicate that both proteins stimulate cell division in tissue cultures more than those of low-risk HPVs, though not as much as those of HPV16. Taken together, the clinical, molecular, and biological data suggest that the novel papillomavirus characterized in the present study is a low- to intermediate-risk HPV.

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References

Chow V, Leong P . Complete nucleotide sequence, genomic organization and phylogenetic analysis of a novel genital human papillomavirus type, HLT7474-S. J Gen Virol. 1999; 80 ( Pt 11):2923-2929. DOI: 10.1099/0022-1317-80-11-2923. View

Barbosa M . The oncogenic role of human papillomavirus proteins. Crit Rev Oncog. 1996; 7(1-2):1-18. DOI: 10.1615/critrevoncog.v7.i1-2.10. View

Wingender E, Chen X, Hehl R, Karas H, Liebich I, Matys V . TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res. 1999; 28(1):316-9. PMC: 102445. DOI: 10.1093/nar/28.1.316. View

Gravitt P, Peyton C, Alessi T, Wheeler C, Coutlee F, Hildesheim A . Improved amplification of genital human papillomaviruses. J Clin Microbiol. 2000; 38(1):357-61. PMC: 88724. DOI: 10.1128/JCM.38.1.357-361.2000. View

Kino N, Sata T, Sato Y, Sugase M, Matsukura T . Molecular cloning and nucleotide sequence analysis of a novel human papillomavirus (Type 82) associated with vaginal intraepithelial neoplasia. Clin Diagn Lab Immunol. 2000; 7(1):91-5. PMC: 95829. DOI: 10.1128/CDLI.7.1.91-95.2000. View

Terai M, Burk R . Complete nucleotide sequence and analysis of a novel human papillomavirus (HPV 84) genome cloned by an overlapping PCR method. Virology. 2001; 279(1):109-15. DOI: 10.1006/viro.2000.0716. View

Terai M, Burk R . Characterization of a novel genital human papillomavirus by overlapping PCR: candHPV86 identified in cervicovaginal cells of a woman with cervical neoplasia. J Gen Virol. 2001; 82(Pt 9):2035-2040. DOI: 10.1099/0022-1317-82-9-2035. View

Schwarz E, Durst M, Demankowski C, Lattermann O, Zech R, Wolfsperger E . DNA sequence and genome organization of genital human papillomavirus type 6b. EMBO J. 1983; 2(12):2341-8. PMC: 555455. DOI: 10.1002/j.1460-2075.1983.tb01744.x. View

Boukamp P, Petrussevska R, Breitkreutz D, Hornung J, Markham A, Fusenig N . Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol. 1988; 106(3):761-71. PMC: 2115116. DOI: 10.1083/jcb.106.3.761. View

10.

McBride A, Byrne J, Howley P . E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain. Proc Natl Acad Sci U S A. 1989; 86(2):510-4. PMC: 286500. DOI: 10.1073/pnas.86.2.510. View

11.

Munger K, Werness B, Dyson N, Phelps W, Harlow E, Howley P . Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 1989; 8(13):4099-105. PMC: 401588. DOI: 10.1002/j.1460-2075.1989.tb08594.x. View

12.

Gage J, Meyers C, WETTSTEIN F . The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J Virol. 1990; 64(2):723-30. PMC: 249166. DOI: 10.1128/JVI.64.2.723-730.1990. View

13.

Snijders P, van den Brule A, Schrijnemakers H, Snow G, Meijer C, Walboomers J . The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes. J Gen Virol. 1990; 71 ( Pt 1):173-81. DOI: 10.1099/0022-1317-71-1-173. View

14.

Resnick R, Cornelissen M, Wright D, Eichinger G, Fox H, Ter Schegget J . Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers. J Natl Cancer Inst. 1990; 82(18):1477-84. DOI: 10.1093/jnci/82.18.1477. View

15.

Barbosa M, Vass W, Lowy D, Schiller J . In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J Virol. 1991; 65(1):292-8. PMC: 240516. DOI: 10.1128/JVI.65.1.292-298.1991. View

16.

Farr A, Wang H, Kasher M, Roman A . Relative enhancer activity and transforming potential of authentic human papillomavirus type 6 genomes from benign and malignant lesions. J Gen Virol. 1991; 72 ( Pt 3):519-26. DOI: 10.1099/0022-1317-72-3-519. View

17.

Williamson A, Rybicki E . Detection of genital human papillomaviruses by polymerase chain reaction amplification with degenerate nested primers. J Med Virol. 1991; 33(3):165-71. DOI: 10.1002/jmv.1890330305. View

18.

Rodu B, Christian C, Synder R, Ray R, Miller D . Simplified PCR-based detection and typing strategy for human papillomaviruses utilizing a single oligonucleotide primer set. Biotechniques. 1991; 10(5):632-7. View

19.

Snijders P, Meijer C, Walboomers J . Degenerate primers based on highly conserved regions of amino acid sequence in papillomaviruses can be used in a generalized polymerase chain reaction to detect productive human papillomavirus infection. J Gen Virol. 1991; 72 ( Pt 11):2781-6. DOI: 10.1099/0022-1317-72-11-2781. View

20.

Smits H, Tieben L, Jebbink M, Minnaar R, Jansen C, Ter Schegget J . Detection and typing of human papillomaviruses present in fixed and stained archival cervical smears by a consensus polymerase chain reaction and direct sequence analysis allow the identification of a broad spectrum of human papillomavirus types. J Gen Virol. 1992; 73 ( Pt 12):3263-8. DOI: 10.1099/0022-1317-73-12-3263. View