Role of Endothelin-1 in Lung Disease

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2001 Nov 1

PMID 11686871

Citations 66

Authors

K A Fagan

I F McMurtry

D M Rodman

Affiliations

Soon will be listed here.

Abstract

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

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References

Lee S, Shroyer K, Markham N, Cool C, Voelkel N, Tuder R . Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest. 1998; 101(5):927-34. PMC: 508641. DOI: 10.1172/JCI1910. View

Ali H, Loizidou M, Dashwood M, Savage F, SHEARD C, Taylor I . Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ET(A) antagonists. Gut. 2000; 47(5):685-8. PMC: 1728110. DOI: 10.1136/gut.47.5.685. View

Markewitz B, Kohan D, Michael J . Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells. Am J Physiol. 1995; 269(2 Pt 1):L215-20. DOI: 10.1152/ajplung.1995.269.2.L215. View

Giaid A, Hamid Q, Springall D, Yanagisawa M, Shinmi O, Sawamura T . Detection of endothelin immunoreactivity and mRNA in pulmonary tumours. J Pathol. 1990; 162(1):15-22. DOI: 10.1002/path.1711620105. View

Tamaoki J, Kanemura T, Sakai N, Isono K, Kobayashi K, Takizawa T . Endothelin stimulates ciliary beat frequency and chloride secretion in canine cultured tracheal epithelium. Am J Respir Cell Mol Biol. 1991; 4(5):426-31. DOI: 10.1165/ajrcmb/4.5.426. View

Odoux C, Crestani B, Lebrun G, Rolland C, Aubin P, Seta N . Endothelin-1 secretion by alveolar macrophages in systemic sclerosis. Am J Respir Crit Care Med. 1997; 156(5):1429-35. DOI: 10.1164/ajrccm.156.5.96-11004. View

Zheng L, Tipoe G, Lam W, Ho J, Shum I, Ooi G . Endothelin-1 in stable bronchiectasis. Eur Respir J. 2000; 16(1):146-9. DOI: 10.1034/j.1399-3003.2000.16a26.x. View

Abraham D, Vancheeswaran R, Dashwood M, Rajkumar V, Pantelides P, Xu S . Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Am J Pathol. 1997; 151(3):831-41. PMC: 1857854. View

Chalmers G, MacLeod K, Thomson L, Little S, Patel K, McSharry C . Sputum cellular and cytokine responses to inhaled endothelin-1 in asthma. Clin Exp Allergy. 1999; 29(11):1526-31. DOI: 10.1046/j.1365-2222.1999.00496.x. View

10.

Halim A, Kanayama N, El Maradny E, Maehara K, Terao T . Activated neutrophil by endothelin-1 caused tissue damage in human umbilical cord. Thromb Res. 1995; 77(4):321-7. DOI: 10.1016/0049-3848(95)93835-n. View

11.

Shahar I, Fireman E, Topilsky M, Grief J, Schwarz Y, Kivity S . Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. Int J Immunopharmacol. 1999; 21(11):759-75. DOI: 10.1016/s0192-0561(99)00056-9. View

12.

Ong A, Jowett T, Firth J, Burton S, Karet F, Fine L . An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int. 1995; 48(2):390-401. DOI: 10.1038/ki.1995.307. View

13.

Hassoun P, Thappa V, Landman M, Fanburg B . Endothelin 1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med. 1992; 199(2):165-70. DOI: 10.3181/00379727-199-43342. View

14.

Michael J, Markewitz B, Kohan D . Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells. Am J Physiol. 1997; 273(4):L768-74. DOI: 10.1152/ajplung.1997.273.4.L768. View

15.

Li H, Chen S, Chen Y, Meng Q, Durand J, Oparil S . Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol (1985). 1994; 77(3):1451-9. DOI: 10.1152/jappl.1994.77.3.1451. View

16.

Guidry C, Hook M . Endothelins produced by endothelial cells promote collagen gel contraction by fibroblasts. J Cell Biol. 1991; 115(3):873-80. PMC: 2289172. DOI: 10.1083/jcb.115.3.873. View

17.

Sunose Y, Takeyoshi I, Ohwada S, Iwazaki S, Aiba M, Tomizawa N . The effect of FK409-a nitric oxide donor-on canine lung transplantation. J Heart Lung Transplant. 2000; 19(3):298-309. DOI: 10.1016/s1053-2498(99)00140-0. View

18.

Aguirre J, Morrell N, Long L, Clift P, Upton P, Polak J . Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2000; 278(5):L981-7. DOI: 10.1152/ajplung.2000.278.5.L981. View

19.

Langleben D, Barst R, Badesch D, GROVES B, Tapson V, Murali S . Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension. Circulation. 1999; 99(25):3266-71. DOI: 10.1161/01.cir.99.25.3266. View

20.

Stelzner T, OBrien R, Yanagisawa M, Sakurai T, Sato K, Webb S . Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol. 1992; 262(5 Pt 1):L614-20. DOI: 10.1152/ajplung.1992.262.5.L614. View