Heat Shock Proteins in the Photobiology of Human Skin

All organisms respond to sudden environmental changes with the increased transcription of genes belonging to the family of heat shock proteins (hsps). Hsp-inducing stress factors include elevated temperatures, alcohol, heavy metals, oxidants, and agents leading to protein denaturation. The induction of heat shock proteins is followed by a transient state of increased resistance to further stress and the heat shock response is generally thought to represent an evolutionary conserved adaptive mechanism to cope with hostile environmental conditions. Since the skin as a barrier organ has to cope with the potentially harmful consequences of exposure to ultraviolet radiation (UV), it appears reasonable to question whether hsps constitute a natural defence mechanism against UV. Hsps have been detected in resting as well as in stressed epidermal and dermal cells and overexpression of hsps is associated with increased resistance to UV-induced cell death. Furthermore, UV itself is able to induce the expression of specific hsps. Thus, hsps might provide an adaptive cellular response to increasing UV and enhancing the expression of hsps might turn out as a new way to deal with the immediate and long-term consequences of UV exposure. Prerequisite for the utilization of this concept is the development of non-toxic heat shock inducers and their evaluation for clinical efficacy and safety.