HIV-1 Reverse Transcriptase and Integrase Enzymes Physically Interact and Inhibit Each Other

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2001 Oct 30

PMID 11682056

Citations 27

Authors

T Tasara

G Maga

M O Hottiger

U Hubscher

Affiliations

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Abstract

Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.

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