Article: Evaluation of a live, attenuated recombinant influenza vaccine in high school children

A live, attenuated, recombinant influenza vaccine (Alice strain) administered intranasally was evaluated in high school students and compared with intranasal placebo and subcutaneous, inactivated, bivalent influenza vaccine. The Alice strain was antigenic, increasing the geometric mean titer (GMT) from a prestudy level of 30.2 to a postvaccine level of 189.6. The inactivated vaccine increased the GMT from 32.9 to 361.8. There was no increase in the GMT among the placebo recipients. The Alice strain produced little reaction. With an antigenic, safe, acceptable, live, attenuated influenza vaccine available, immunization on a widespread basis should be considered.

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References

1.

JORDAN Jr W, DENNY Jr F, Badger G, CURTISS C, DINGLE J, OSEASOHN R . A study of illness in a group of Cleveland families. XVII. The occurrence of Asian influenza. Am J Hyg. 1958; 68(2):190-212. DOI: 10.1093/oxfordjournals.aje.a119962. View

2.

Dull H . Vaccinology and selected virus diseases. Adv Intern Med. 1971; 17:143-70. View

3.

PHILLIPS C, Phillips C, Hodgkin W, FORSYTH B, RUBIN B, Geraghty M . Killed subunit influenza vaccine in children. Pediatrics. 1973; 52(3):416-9. View

4.

Stuart-Harris C . Influenza--the problems and the future. Med J Aust. 1973; 1(SP1):42-7. View

5.

DAVENPORT F . Control of influenza. Med J Aust. 1973; 1(SP1):33-8. DOI: 10.5694/j.1326-5377.1973.tb111174.x. View

6.

Couch R, DOUGLAS Jr R, Fedson D, KASEL J . Correlated studies of a recombinant influenza-virus vaccine. 3. Protection against experimental influenza in man. J Infect Dis. 1971; 124(5):473-80. DOI: 10.1093/infdis/124.5.473. View

7.

Van Kirk J, Mills J, Chanock R . Evaluation of low temperature grown influenza A2-Hong Kong virus in volunteers. Proc Soc Exp Biol Med. 1971; 136(1):34-41. DOI: 10.3181/00379727-136-35187. View

8.

Leibovitz A, Coultrip R, KILBOURNE E, LEGTERS L, Smith C, Chin J . Correlated studies of a recombinant influenza-virus vaccine. IV. Protection against naturally occurring influenza in military trainees. J Infect Dis. 1971; 124(5):481-7. DOI: 10.1093/infdis/124.5.481. View

9.

KILBOURNE E, SCHULMAN J, Schild G, Schloer G, Swanson J, Bucher D . Related studies of a recombinant influenza-virus vaccine. I. Derivation and characterization of virus and vaccine. J Infect Dis. 1971; 124(5):449-62. DOI: 10.1093/infdis/124.5.449. View

10.

Krugman S . Present status of measles and rubella immunization in the United States: a medical progress report. J Pediatr. 1971; 78(1):1-16. DOI: 10.1016/s0022-3476(71)80259-7. View

11.

Monto A, DAVENPORT F, Napier J, FRANCIS Jr T . Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren. J Infect Dis. 1970; 122(1):16-25. DOI: 10.1093/infdis/122.1-2.16. View

Evaluation of a Live, Attenuated Recombinant Influenza Vaccine in High School Children