Association Between Lithium Use and Thyrotoxicosis Caused by Silent Thyroiditis

Overview

Journal Clin Endocrinol (Oxf)

Specialty Endocrinology

Date 2001 Oct 27

PMID 11678833

Citations 18

Authors

K K Miller

G H Daniels

Affiliations

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Abstract

Objective: To determine the incidence of silent thyroiditis in lithium users and characterize lithium-associated thyrotoxicosis.

Design: Retrospective record review.

Patients: 400 consecutive patients (300 with Graves' disease and 100 with silent thyroiditis) who underwent radioiodine scanning of the thyroid.

Measurements: Odds of lithium exposure.

Results: The odds of lithium exposure were increased 4.7-fold in patients with silent thyroiditis compared with those with Graves' disease (95% CI: 1.3, 17). Lithium-associated silent thyroiditis occurred with an incidence rate of approximately 1.3 cases per 1000 person-years, and lithium-associated thyrotoxicosis occurred with an incidence rate of approximately 2.7 cases per 1000 person-years, higher than the reported incidence rates of silent thyroiditis (< 0.03-0.28 cases per 1000 person-years) and of thyrotoxicosis (0.8-1.2 cases per 1000 person-years) in the general population.

Conclusion: Thyrotoxicosis caused by silent thyroiditis might be associated with lithium use.

Citing Articles

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Zhou Q, Xue S, Zhang L, Chen G Front Endocrinol (Lausanne). 2022; 13:904889.

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Elevated Thyroxine Concentration and Lithium Intoxication-An Analysis Based on the LiSIE Retrospective Cohort Study.

Lieber I, Ott M, Lundqvist R, Eliasson M, Sandlund M, Werneke U J Clin Med. 2022; 11(11).

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