Interleukin-4 Receptor Alpha Gene Variants and Allergic Disease

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2001 Oct 23

PMID 11667956

Citations 2

Authors

I P Hall

Affiliations

Soon will be listed here.

Abstract

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme.

Citing Articles

IDENTIFYING INDIVIDUAL STRESS SUSCEPTIBILITY USING GENOMIC AND IMMUNE BIOMARKERS.

Marshall G Trans Am Clin Climatol Assoc. 2019; 130:235-245.

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