The Genetic Control of Antibody Affinity in Mice

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1975 Sep 1

PMID 1165110

Citations 22

Authors

F E Katz

M W Steward

Affiliations

Soon will be listed here.

Abstract

Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P less than 0-001). The selection on the basis of KR did not result in a corresponding selection for antibody levels (Abt), which were not significantly different in the two lines. These results indicate that antibody affinity is a genetically controlled parameter of the immune response. Furthermore, this control appears to be expressed by a mechanism which is independent of the amount of antibody produced.

Citing Articles

No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children.

Heino L, Lonnrot M, Knip M, Kupila A, Erkkila S, Toivonen A Clin Exp Immunol. 2001; 126(3):432-6.

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The effect of protein deficiency on the development of chronic antigen-antibody complex disease in mice.

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Chronic antigen-antibody-complex glomerulonephritis in mice.

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The induction of chronic antigen-antibody complex disease in selectively bred mice producing either high or low affinity antibody to protein antigens.

Devey M, Steward M Immunology. 1980; 41(2):303-11.

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Antigen feeding modifies the course of antigen-induced immune complex disease.

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References

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10.

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