Retinoic Acid Metabolism
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The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI). These latter enzymes protect against premature exposure to RA, and the implications of these findings are discussed.
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PMID: 35883425 PMC: 9312697. DOI: 10.3390/biom12070869.
9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.
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A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis.
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PMID: 22415012 PMC: 3388133. DOI: 10.2119/molmed.2012.00094.
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PMID: 22179182 DOI: 10.1007/s00795-010-0528-x.
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