HLA Class II Antibodies in Transfusion-related Acute Lung Injury

Overview

Journal Transfusion

Specialty Hematology

Date 2001 Oct 19

PMID 11606823

Citations 33

Authors

P M Kopko

M A Popovsky

M R Mackenzie

T G Paglieroni

K N Muto

P V Holland

Affiliations

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Abstract

Background: Transfusion-related acute lung injury (TRALI) is a serious, sometimes fatal, complication of transfusion. Granulocyte and HLA class I antibodies present in blood donors have been associated with TRALI. HLA class II antibodies have recently been described in a few cases of TRALI.

Study Design And Methods: Donors involved in TRALI reactions reported to a blood center over an 18-month period were tested for HLA class I and II antibodies as well as granulocyte antibodies, if HLA antibodies were not identified.

Results: HLA class II antibodies were identified, in at least one donor, in 7 (64%) of 11 cases of TRALI. HLA class I antibodies were identified in combination with HLA class II antibodies in 5 of these 7 cases. HLA class I antibodies were exclusively identified in 2 cases. Granulocyte antibodies were identified in 1 case, and no antibodies were identified in another.

Conclusion: In addition to HLA class I antibodies, HLA class II antibodies are associated with TRALI. Testing of donors for HLA class II antibodies as well as HLA class I and granulocyte antibodies is recommended as part of the investigation of suspected cases of TRALI.

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Casale M, Di Girolamo M, Di Maio N, Tomeo R, Iengo M, Scianguetta S Ann Hematol. 2023; 103(2):623-629.

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Sivakaanthan A, Swain F, Pahn G, Goodison K, Gutta N, Holdsworth R Blood Transfus. 2022; 20(6):454-464.

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Vlaar A, Toy P, Fung M, Looney M, Juffermans N, Bux J Transfusion. 2019; 59(7):2465-2476.

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