Study of the Fine Structure of Adeno-associated Virus DNA with Bacterial Restriction Endonucleases

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1975 Sep 1

PMID 1159899

Citations 15

Authors

K I Berns

J Kort

K H Fife

E W GROGAN

I Spear

Affiliations

Soon will be listed here.

Abstract

A physical map of the adeno-associated virus type 2 genome has been constructed on the basis of the five fragments produced by the restriction endonucleases HindII + III from Hemophilus influenzae. There are three endo R-HindII cleavage sites and one endo R-HindIII site. Evidence has been obtained to support the existence of two nucleotide sequence permutations in adeno-associated virus DNA, the start points of which have been estimated to be separated by 1% of the genome. The three cleavage fragments produced by endo R-Eco RI have been ordered and oriented with respect to the endo R-HindII + III cleavage map.

Citing Articles

Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.

Yang C, Xiao X, Zhu X, Ansardi D, Epstein N, Frey M J Virol. 1997; 71(12):9231-47.

PMID: 9371582 PMC: 230226. DOI: 10.1128/JVI.71.12.9231-9247.1997.

Nucleotide sequence and organization of the adeno-associated virus 2 genome.

Srivastava A, Lusby E, Berns K J Virol. 1983; 45(2):555-64.

PMID: 6300419 PMC: 256449. DOI: 10.1128/JVI.45.2.555-564.1983.

Mapping of the 5' termini of two adeno-associated virus 2 RNAs in the left half of the genome.

Lusby E, Berns K J Virol. 1982; 41(2):518-26.

PMID: 6281463 PMC: 256780. DOI: 10.1128/JVI.41.2.518-526.1982.

Physical mapping of adeno-associated virus serotype 4 DNA.

Muster C, Lee Y, Newbold J, Leis J J Virol. 1980; 35(3):653-61.

PMID: 6252330 PMC: 288859. DOI: 10.1128/JVI.35.3.653-661.1980.

Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA.

Lusby E, Fife K, Berns K J Virol. 1980; 34(2):402-9.

PMID: 6246271 PMC: 288718. DOI: 10.1128/JVI.34.2.402-409.1980.

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