Detection and Typing of Human Papillomavirus DNA in Penile Carcinoma: Evidence for Multiple Independent Pathways of Penile Carcinogenesis

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2001 Oct 5

PMID 11583947

Citations 106

Authors

M A Rubin

B Kleter

M Zhou

G Ayala

A L Cubilla

W G Quint

E C Pirog

Affiliations

Soon will be listed here.

Abstract

To clarify the role of human papillomavirus (HPV) in penile cancer we evaluated the prevalence of HPV DNA in different histological subtypes of penile carcinoma, dysplasia, and condyloma using a novel, sensitive SPF10 HPV polymerase chain reaction assay and a novel genotyping line probe assay, allowing simultaneous identification of 25 different HPV types. Formalin-fixed, paraffin-embedded tissue samples were collected from the United States and Paraguay. HPV DNA was detected in 42% cases of penile carcinoma, 90% cases of dysplasia, and 100% cases of condyloma. There were significant differences in HPV prevalence in different histological cancer subtypes. Although keratinizing squamous cell carcinoma and verrucous carcinoma were positive for HPV DNA in only 34.9 and 33.3% of cases, respectively, HPV DNA was detected in 80% of basaloid and 100% of warty tumor subtypes. There was no significant difference in HPV prevalence between cases from Paraguay and the United States. In conclusion, the overall prevalence of HPV DNA in penile carcinoma (42%) is lower than that in cervical carcinoma (approximately 100%) and similar to vulvar carcinoma (approximately 50%). In addition, specific histological subtypes of penile cancer--basaloid and warty--are consistently associated with HPV, however, only a subset of keratinizing and verrucous penile carcinomas is positive for HPV DNA, and thus these two tumor groups seem to develop along different pathogenetic pathways.

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References

Frisch M, Goodman M . Human papillomavirus-associated carcinomas in Hawaii and the mainland U.S. Cancer. 2000; 88(6):1464-9. DOI: 10.1002/(sici)1097-0142(20000315)88:6<1464::aid-cncr26>3.0.co;2-o. View

Bosch F, Manos M, Munoz N, Sherman M, Jansen A, Peto J . Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995; 87(11):796-802. DOI: 10.1093/jnci/87.11.796. View

Cubilla A, Velazques E, Reuter V, Oliva E, Mihm Jr M, Young R . Warty (condylomatous) squamous cell carcinoma of the penis: a report of 11 cases and proposed classification of 'verruciform' penile tumors. Am J Surg Pathol. 2000; 24(4):505-12. DOI: 10.1097/00000478-200004000-00004. View

Wabinga H, Parkin D, Wabwire-Mangen F, Nambooze S . Trends in cancer incidence in Kyadondo County, Uganda, 1960-1997. Br J Cancer. 2000; 82(9):1585-92. PMC: 2363394. DOI: 10.1054/bjoc.1999.1071. View

Gillison M, Koch W, Capone R, Spafford M, Westra W, Wu L . Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000; 92(9):709-20. DOI: 10.1093/jnci/92.9.709. View

Pirog E, Kleter B, Olgac S, Bobkiewicz P, Lindeman J, Quint W . Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. Am J Pathol. 2000; 157(4):1055-62. PMC: 1850168. DOI: 10.1016/S0002-9440(10)64619-6. View

Saiki R, Scharf S, Faloona F, Mullis K, Horn G, Erlich H . Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 1985; 230(4732):1350-4. DOI: 10.1126/science.2999980. View

McCance D, Kalache A, Ashdown K, Andrade L, Menezes F, Smith P . Human papillomavirus types 16 and 18 in carcinomas of the penis from Brazil. Int J Cancer. 1986; 37(1):55-9. DOI: 10.1002/ijc.2910370110. View

Toki T, Kurman R, Park J, Kessis T, Daniel R, Shah K . Probable nonpapillomavirus etiology of squamous cell carcinoma of the vulva in older women: a clinicopathologic study using in situ hybridization and polymerase chain reaction. Int J Gynecol Pathol. 1991; 10(2):107-25. DOI: 10.1097/00004347-199104000-00001. View

10.

Cupp M, Malek R, Goellner J, Smith T, Espy M . The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J Urol. 1995; 154(3):1024-9. View

11.

Gregoire L, Cubilla A, Reuter V, Haas G, Lancaster W . Preferential association of human papillomavirus with high-grade histologic variants of penile-invasive squamous cell carcinoma. J Natl Cancer Inst. 1995; 87(22):1705-9. DOI: 10.1093/jnci/87.22.1705. View

12.

Vincent-Salomon A, De La Rochefordiere A, Salmon R, Validire P, Zafrani B, Sastre-Garau X . Frequent association of human papillomavirus 16 and 18 DNA with anal squamous cell and basaloid carcinoma. Mod Pathol. 1996; 9(6):614-20. View

13.

de Roda Husman A, Walboomers J, van den Brule A, Meijer C, Snijders P . The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995; 76 ( Pt 4):1057-62. DOI: 10.1099/0022-1317-76-4-1057. View

14.

Dianzani C, Bucci M, Pierangeli A, Calvieri S, Degener A . Association of human papillomavirus type 11 with carcinoma of the penis. Urology. 1998; 51(6):1046-8. DOI: 10.1016/s0090-4295(98)00105-8. View

15.

Cubilla A, Reuter V, Gregoire L, Ayala G, Ocampos S, Lancaster W . Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases. Am J Surg Pathol. 1998; 22(6):755-61. DOI: 10.1097/00000478-199806000-00014. View

16.

Deligeorgi-Politi H, Liapis A . Human papilloma virus in verrucus carcinoma of the vulva: an immunopathological study of three cases. Eur J Gynaecol Oncol. 1998; 19(3):319-20. View

17.

Kleter B, van Doorn L, Ter Schegget J, Schrauwen L, van Krimpen K, Burger M . Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of anogenital human papillomaviruses. Am J Pathol. 1998; 153(6):1731-9. PMC: 1866345. DOI: 10.1016/S0002-9440(10)65688-X. View

18.

Frisch M, Fenger C, van den Brule A, Sorensen P, Meijer C, Walboomers J . Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999; 59(3):753-7. View

19.

van Muyden R, ter Harmsel B, Smedts F, Hermans J, Kuijpers J, Raikhlin N . Detection and typing of human papillomavirus in cervical carcinomas in Russian women: a prognostic study. Cancer. 1999; 85(9):2011-6. View

20.

Kleter B, van Doorn L, Schrauwen L, Molijn A, Sastrowijoto S, Ter Schegget J . Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogenital human papillomavirus. J Clin Microbiol. 1999; 37(8):2508-17. PMC: 85270. DOI: 10.1128/JCM.37.8.2508-2517.1999. View