Characterization of Poly(L-lactic Acid) Microspheres Loaded with Holmium Acetylacetonate

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2001 Sep 29

PMID 11575483

Citations 12

Authors

J F Nijsen

M J van Steenbergen

H Kooijman

H Talsma

M van de Weert

P P van Rijk

A De Witte

A D Van Schip

W E Hennink

Affiliations

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Abstract

Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres.

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