Xenon-induced Flow Activation in Patients with Cerebral Insult Who Undergo Xenon-enhanced CT Blood Flow Studies

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2001 Sep 18

PMID 11559502

Citations 4

Authors

P Horn

P Vajkoczy

C Thome

E Muench

L Schilling

P Schmiedek

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Stable xenon-enhanced CT ((s)Xe/CT) has gained wide acceptance in the assessment of regional cerebral blood flow (rCBF) in patients with intracranial abnormalities. The aim of this study was to test whether the contrast medium (ie, (s)Xe) itself directly induces relevant changes in rCBF, thereby distorting any valid determination of cerebral perfusion by using (s)Xe/CT.

Methods: To characterize the degree and temporal dynamics of (s)Xe-induced flow activation, a thermal diffusion (TD)-based microprobe was placed subcortically into the frontal lobe on either hemisphere to assess rCBF (TD-rCBF) continuously in 23 patients (mean age, 55 +/- 18 years) with severe intracranial insult who were undergoing (s)Xe/CT.

Results: In 35, the (s)Xe/CT studies TD-rCBF rose from 25 +/- 17 mL/100 g per minute (range, 5-42 mL/100 g per minute) before (s)Xe administration to 28 +/- 21 mL/100 g per minute (range, 6-46 mL/100 g per minute) after arterial (s)Xe saturation was reached. Analysis of the flow activation curve showed a logarithmic shape with an increase in TD-rCBF between 3% and 7% within the first 76 seconds of (s)Xe wash-in (12% after 190 seconds) and showed no further augmentation until the end of the blood flow study.

Conclusion: The observed (s)Xe-induced rCBF activation, which showed significant inter- and intraindividual variability, might lead to overestimation of rCBF in patients with severe intracranial insult. The obtained flow activation curve provides essential information that may allow subsequent refinement of the methodology, aiming to further minimize the influence of (s)Xe-induced rCBF activation on rCBF calculations when using (s)Xe/CT technology.

Citing Articles

Physiologic Effects of Xenon in Xenon-CT Cerebral Blood Flow Studies on Comatose Patients.

Kosty J, Kofke W, Maloney-Wilensky E, Frangos S, Levine J, Leroux P Transl Stroke Res. 2013; 3(3):375-80.

PMID: 24323813 DOI: 10.1007/s12975-012-0183-8.

Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults.

Kim M, Durduran T, Frangos S, Edlow B, Buckley E, Moss H Neurocrit Care. 2009; 12(2):173-80.

PMID: 19908166 PMC: 2844468. DOI: 10.1007/s12028-009-9305-x.

Cerebrovascular insufficiency as the criterion for revascularization procedures in selected patients: a correlation study of xenon contrast-enhanced CT and PWI.

Schubert G, Weinmann C, Seiz M, Gerigk L, Weiss C, Horn P Neurosurg Rev. 2008; 32(1):29-35.

PMID: 18791753 DOI: 10.1007/s10143-008-0159-z.

Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results.

Hemphill 3rd J, Smith W, Christian Sonne D, Morabito D, Manley G AJNR Am J Neuroradiol. 2005; 26(5):1095-100.

PMID: 15891166 PMC: 8158594.

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