Immunology. Long Live the Mature B Cell--a Baffling Mystery Resolved

Overview

Journal Science

Specialty Science

Date 2001 Sep 15

PMID 11557866

Citations 7

Authors

T J Waldschmidt

R J Noelle

Affiliations

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Abstract

What determines whether transitional B cells newly emerged from the bone marrow will differentiate further to become mature, long-lived, circulating B lymphocytes? In a Perspective, Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thompson et al., Schiemann et al.).

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