Probable Genetic Linkage Between a Locus for Human Urinary Pepsinogen and the HL-A Loci

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1975 Jul 1

PMID 1155457

Citations 4

Authors

L R Weitkamp

P L Townes

A G May

Affiliations

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Abstract

The genetic basis of familial variation in the relative intensities of human urinary pepsinogen isozymes is not completely clear from family studies. An investigation of the linkage relationships of pepsinogen isozyme 5, considering only segregation for the presence or absence of Pg 5, yields a peak lod score of 4.1 at theta = .1 for linkage with HL-A1 or HL-A2. Added to data from segregation interpreted according to a scheme proposed for the inheritance of intensity differences in Pg 5, the peak lod score becomes 3.0 at theta = .2. Data derived from the segregation of pepsinogen isozyme 4, possibly determined by an allele to that controlling the presence or absence of Pg 5, further reduces the total lod score at theta = .2 to 2.9. The results indicate probable linkage between a locus for urinary pepsinogen and the HL-A loci, but are insufficient to permit any conclusion concerning possible heterogeneity in the linkage relationships of Pg 4 and Pg 5 to HL-A.

Citing Articles

Genetic variation of urinary pepsinogen and its probable linkage to albinism in the rat.

Cramer D Immunogenetics. 1981; 13(6):555-8.

PMID: 7287084 DOI: 10.1007/BF00343723.

Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man.

Nadeau J, Kompf J, Siebert G, Taylor B Biochem Genet. 1981; 19(5-6):465-74.

PMID: 6457599 DOI: 10.1007/BF00484619.

Pepsinogen.

Hirschowitz B Postgrad Med J. 1984; 60(709):743-50.

PMID: 6438618 PMC: 2418061. DOI: 10.1136/pgmj.60.709.743.

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

Zelle B, Geurts van Kessel A, de Wit J, Evers P, Arwert F, Pronk J Hum Genet. 1985; 70(4):337-40.

PMID: 3839486 DOI: 10.1007/BF00295373.

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