A Developmental Study of Girls with Trisomy X

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1975 Jan 1

PMID 1155452

Citations 10

Authors

K Tennes

M Puck

K Bryant

W Frankenburg

A Robinson

Affiliations

Soon will be listed here.

Abstract

Development of 11 girls (ages 2-10 years) with 47,XXX karyotype identified in a newborn survey is compared with eight girls having a mosaic sex chromatin pattern and with the normal siblings of each group. Delay in early motor development and speech, a mild intellectual deficit, and disturbance in interpersonal relationships occurred in one-third of the index cases, a higher frequency than in the comparison groups. two-thirds were considered normal and adequately adjusted. No consistent phenotype was found.

Citing Articles

Refractory hypokalemia with sexual dysplasia and infertility caused by 17α-hydroxylase deficiency and triple X syndrome: A case report.

Yao J, Xu M, Zhang Y, Wang B, Li M, Gao L Open Life Sci. 2023; 18(1):20220548.

PMID: 36820210 PMC: 9938537. DOI: 10.1515/biol-2022-0548.

A case-control study of brain structure and behavioral characteristics in 47,XXX syndrome.

Lenroot R, Blumenthal J, Wallace G, Clasen L, Lee N, Giedd J Genes Brain Behav. 2014; 13(8):841-9.

PMID: 25287572 PMC: 4241137. DOI: 10.1111/gbb.12180.

Brain morphological abnormalities in 49,XXXXY syndrome: A pediatric magnetic resonance imaging study.

Blumenthal J, Baker E, Lee N, Wade B, Clasen L, Lenroot R Neuroimage Clin. 2013; 2:197-203.

PMID: 23667827 PMC: 3649771. DOI: 10.1016/j.nicl.2013.01.003.

Triple x syndrome with short stature: case report and literature review.

Li M, Zou C, Zhao Z Iran J Pediatr. 2012; 22(2):269-73.

PMID: 23056899 PMC: 3446055.

Effects of sex chromosome aneuploidies on brain development: evidence from neuroimaging studies.

Lenroot R, Lee N, Giedd J Dev Disabil Res Rev. 2009; 15(4):318-27.

PMID: 20014372 PMC: 2996824. DOI: 10.1002/ddrr.86.

References

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