Genome of the Bacterium Streptococcus Pneumoniae Strain R6

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2001 Sep 7

PMID 11544234

Citations 348

Authors

J Hoskins

W E Alborn Jr

J Arnold

L C Blaszczak

S Burgett

B S DeHoff

S T Estrem

L Fritz

D J Fu

W Fuller

C Geringer

R Gilmour

J S Glass

H Khoja

A R Kraft

R E Lagace

D J Leblanc

L N Lee

E J Lefkowitz

J Lu

P Matsushima

S M McAhren

M McHenney

K McLeaster

C W Mundy

T I Nicas

F H Norris

M OGara

R B Peery

G T Robertson

P Rockey

P M Sun

M E Winkler

Y Yang

G Zhao

C A Zook

R H Baltz

S R Jaskunas

P R Rosteck Jr

P L Skatrud

J I Glass

Affiliations

Soon will be listed here.

Abstract

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development.

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