Syndecan-4 and Focal Adhesion Function

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2001 Sep 7

PMID 11544026

Citations 75

Authors

A Woods

J R Couchman

Affiliations

Soon will be listed here.

Abstract

Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.

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