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Matrix Metalloproteinases: They're Not Just for Matrix Anymore!

Overview
Journal Curr Opin Cell Biol
Publisher Elsevier
Specialty Cell Biology
Date 2001 Sep 7
PMID 11544020
Citations 385
Authors
L J McCawley
L M Matrisian
Affiliations
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Abstract

The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of the biological consequence of cleavage indicates that perhaps MMPs should be viewed more as pruning shears, playing sophisticated roles in modulating normal cellular behavior, cell-cell communication and tumor progression.

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