A Highly Efficient 24-condition Matrix for the Crystallization of Nucleic Acid Fragments

Overview

Journal Acta Crystallogr D Biol Crystallogr

Specialty Chemistry

Date 1996 May 1

PMID 11539196

Citations 33

Authors

I Berger

C H Kang

N Sinha

M Wolters

A Rich

Affiliations

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Abstract

A matrix screen is presented with optimized conditions for the crystallization of nucleic acid fragments. The screen consists of 24 conditions only and utilizes minimal amounts of sample. It has been tested on a series of DNA and RNA oligomers, and yielded diffraction-quality crystals of many specimens including drug-DNA complexes. Preliminary X-ray analysis of the crystals is reported.

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