Localization of the Gene for the Intermediate Form of Charcot-Marie-Tooth to Chromosome 10q24.1-q25.1

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2001 Sep 5

PMID 11533914

Citations 15

Authors

K Verhoeven

M Villanova

A Rossi

A Malandrini

P De Jonghe

V Timmerman

Affiliations

Soon will be listed here.

Abstract

Intermediate Charcot-Marie-Tooth neuropathy (CMT) is an inherited sensory motor neuropathy characterized by motor median nerve conduction velocities of 25-45 m/s. We performed a genomewide search in an Italian family with autosomal dominant intermediate CMT and mapped the locus on chromosome 10q. Analysis of key recombinants maps the gene for autosomal dominant intermediate CMT to a 10.7-Mb interval on chromosome 10q24.1-q25.1, between simple tandem repeat markers D10S1709 and D10S1795.

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