Antiphosphatidylserine Antibodies Are Elevated in Normal Tension Glaucoma

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2001 Sep 1

PMID 11529911

Citations 22

Authors

S Kremmer

E Kreuzfelder

R Klein

N Bontke

K P Steuhl

H Grosse-Wilde

Affiliations

Soon will be listed here.

Abstract

The two main entities of open-angle glaucoma are primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Both diseases may be associated with autoimmune processes. Therefore, IgG and IgM antibodies to phospholipids (APL) and their subspecies cardiolipin (ACL), phosphatidylserine (APS) and beta2-glycoprotein (beta2GP) were determined in 43 NTG patients, 40 POAG patients and 40 healthy controls in a prospective study. The most prominent observation was the increase in APS concentrations in NTG patients (IgG 20.6 +/- 2.7 U/ml, IgM 24.4 +/- 3.4 U/ml) compared with POAG patients (IgG 8.8 +/- 1.2 U/ml, IgM 11.0 +/- 1.7), and controls (IgG 7.7 +/- 1.3 U/ml, IgM 12.8 +/- 1.5 U/ml). APS may be important due to their binding specificity to phosphatidylserine molecules which become accessible during apoptosis; this in turn may lead to local thrombosis.

Citing Articles

Evaluating the association between autoimmune disease and normal tension glaucoma: a retrospective case-control study.

Becerra C, Funk R, Kohli D, Hodge D, Roddy G BMC Ophthalmol. 2025; 25(1):73.

PMID: 39934714 PMC: 11817630. DOI: 10.1186/s12886-025-03893-4.

The gut-retina axis: Uncovering the role of autoimmunity in glaucoma development.

Yang Z, Tian D, Zhao X, Luo Y, Chen Y Heliyon. 2024; 10(15):e35516.

PMID: 39170439 PMC: 11336731. DOI: 10.1016/j.heliyon.2024.e35516.

Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort.

Cifuentes-Gonzalez C, Uribe-Reina P, Reyes-Guanes J, Munoz-Ortiz J, Munoz-Vargas P, Rojas-Carabali W Clin Ophthalmol. 2022; 16:2477-2490.

PMID: 35971506 PMC: 9375558. DOI: 10.2147/OPTH.S361243.

Therapeutic Drugs and Devices for Tackling Ocular Hypertension and Glaucoma, and Need for Neuroprotection and Cytoprotective Therapies.

Sharif N Front Pharmacol. 2021; 12:729249.

PMID: 34603044 PMC: 8484316. DOI: 10.3389/fphar.2021.729249.

Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical Applications.

Fernandez-Vega Cueto A, Alvarez L, Garcia M, Alvarez-Barrios A, Artime E, Fernandez-Vega Cueto L Biology (Basel). 2021; 10(8).

PMID: 34439995 PMC: 8389649. DOI: 10.3390/biology10080763.

References

Coleman A . Glaucoma. Lancet. 1999; 354(9192):1803-10. DOI: 10.1016/S0140-6736(99)04240-3. View

Tezel G, Edward D, Wax M . Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch Ophthalmol. 1999; 117(7):917-24. DOI: 10.1001/archopht.117.7.917. View

Tomita G . The optic nerve head in normal-tension glaucoma. Curr Opin Ophthalmol. 2000; 11(2):116-20. DOI: 10.1097/00055735-200004000-00009. View

Rauch J, Meng Q, Tannenbaum H . Lupus anticoagulant and antiplatelet properties of human hybridoma autoantibodies. J Immunol. 1987; 139(8):2598-604. View

Tsakiris D, Osusky R, Kaiser H, Mueri R, Flammer J, Marbet G . Lupus anticoagulants/anticardiolipin antibodies in patients with normal tension glaucoma. Blood Coagul Fibrinolysis. 1992; 3(5):541-5. DOI: 10.1097/00001721-199210000-00004. View

Quigley H, Nickells R, Kerrigan L, Pease M, Thibault D, Zack D . Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci. 1995; 36(5):774-86. View

Shareef S, Walsh J, Sharma S . Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res. 1995; 61(1):33-44. DOI: 10.1016/s0014-4835(95)80056-5. View

Yodfat O, Blank M, Krause I, Shoenfeld Y . The pathogenic role of anti-phosphatidylserine antibodies: active immunization with the antibodies leads to the induction of antiphospholipid syndrome. Clin Immunol Immunopathol. 1996; 78(1):14-20. DOI: 10.1006/clin.1996.0003. View

Galli M, Beretta G, Daldossi M, Bevers E, Barbui T . Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost. 1997; 77(3):486-91. View

10.

Klein R, Berg P . High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders. Eur J Med Res. 1995; 1(1):21-6. View

11.

Lindblom B . Open angle glaucoma and non-central retinal vein occlusion--the chicken or the egg?. Acta Ophthalmol Scand. 1998; 76(3):329-33. DOI: 10.1034/j.1600-0420.1998.760315.x. View

12.

Flammer J, Orgul S . Optic nerve blood-flow abnormalities in glaucoma. Prog Retin Eye Res. 1998; 17(2):267-89. DOI: 10.1016/s1350-9462(97)00006-2. View

13.

Galli M, Barbui T . Prothrombin as cofactor for antiphospholipids. Lupus. 1998; 7 Suppl 2:S37-40. DOI: 10.1177/096120339800700209. View

14.

Meroni P, Del Papa N, Raschi E, Panzeri P, Borghi M, Tincani A . Beta2-glycoprotein I as a 'cofactor' for anti-phospholipid reactivity with endothelial cells. Lupus. 1998; 7 Suppl 2:S44-7. DOI: 10.1177/096120339800700211. View

15.

Branch D, Hatasaka H . Antiphospholipid antibodies and infertility: fact or fallacy. Lupus. 1998; 7 Suppl 2:S90-4. DOI: 10.1177/096120339800700220. View

16.

Tincani A, Spatola L, Cinquini M, Cattaneo R, Meroni P, BALESTRIERI G . Anti beta2-glycoprotein I antibodies: clinical significance. Lupus. 1998; 7 Suppl 2:S107-9. DOI: 10.1177/096120339800700224. View

17.

Bevers E, Comfurius P, Dekkers D, Harmsma M, ZWAAL R . Regulatory mechanisms of transmembrane phospholipid distributions and pathophysiological implications of transbilayer lipid scrambling. Lupus. 1998; 7 Suppl 2:S126-31. DOI: 10.1177/096120339800700228. View

18.

Dreyer E, Lipton S . New perspectives on glaucoma. JAMA. 1999; 281(4):306-8. DOI: 10.1001/jama.281.4.306. View

19.

Kutteh W, Rote N, Silver R . Antiphospholipid antibodies and reproduction: the antiphospholipid antibody syndrome. Am J Reprod Immunol. 1999; 41(2):133-52. DOI: 10.1111/j.1600-0897.1999.tb00087.x. View

20.

Schwartz M, Yoles E . Self-destructive and self-protective processes in the damaged optic nerve: implications for glaucoma. Invest Ophthalmol Vis Sci. 2000; 41(2):349-51. View