Antileukemic Activity of Bidens Pilosa L. Var. Minor (Blume) Sherff and Houttuynia Cordata Thunb

Overview

Journal Am J Chin Med

Specialty Rehabilitation Medicine

Date 2001 Aug 31

PMID 11527072

Citations 34

Authors

J S Chang

L C Chiang

C C Chen

L T Liu

K C Wang

C C Lin

Affiliations

Soon will be listed here.

Abstract

To evaluate the anti-leukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb., cytotoxicity tests with an XTT-based colorimetric assay were used. Five leukemic cell lines, namely L1210, U937, K562, Raji and P3HR1, were cultured with hot water extracts of B. pilosa var. minor or H. cordata. Hot water extracts of B. pilosa var. minor inhibited these five leukemic cells with IC50s between 145 microg/ml and 586 microg/ml. The effect was greatest on four cell lines, namely L1210, P3MR1, Raji and K562, with IC50s below 200 microg/ml and a selective index of more than 5. Hot water extract of H. cordata inhibited these five leukemic cells with IC50s between 478 microg/ml and 662 microg/ml. The selective index was between 1.5 and 2.1. B. pilosa var. minor was more effective than H. cordata in inhibiting most of the leukemic cells in our study. We suggest that B. pilosa L. var. minor (Blume) Sherff may prove to be a useful medicinal plant for treating leukemia.

Citing Articles

Quercetin Derivatives from Bidens pilosa Suppressed Cell Proliferation via Inhibition of RSK2 Kinase and Aldose Reductase Enzymes: UPLC-MS/MS, GC-MS, In Vitro, and Computational Studies.

Ali D, El-Haddad A, Mohamed H, El-Bassuony A, Hegab M, AbdElgayed G Appl Biochem Biotechnol. 2025; .

PMID: 39760986 DOI: 10.1007/s12010-024-05134-8.

Decrease in wind stress leads to an increase in the above ground morphology and number of seeds of an invasive alien species, (Asteraceae).

Shiba M, Kobayashi N, Harada S, Fukuda T Front Plant Sci. 2024; 15:1445437.

PMID: 39582631 PMC: 11581870. DOI: 10.3389/fpls.2024.1445437.

Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics.

Moorthy K, Chang K, Huang H, Wu W, Chiang C Antioxidants (Basel). 2024; 13(1).

PMID: 38247457 PMC: 10812406. DOI: 10.3390/antiox13010032.

A L. Non-Polar Extract Modulates the Polarization of Human Macrophages and Dendritic Cells into an Anti-Inflammatory Phenotype.

Rodriguez Mesa X, Contreras Bolanos L, Costa G, Mejia A, Santander Gonzalez S Molecules. 2023; 28(20).

PMID: 37894572 PMC: 10608814. DOI: 10.3390/molecules28207094.

Anti-cancer Effect and Active Phytochemicals of Houttuynia cordata Thunb. against Human Breast Cancer Cells.

Inthi P, Pandith H, Kongtawelert P, Banjerdpongchai R Asian Pac J Cancer Prev. 2023; 24(4):1265-1274.

PMID: 37116149 PMC: 10352729. DOI: 10.31557/APJCP.2023.24.4.1265.