RNA Interference: Listening to the Sound of Silence

Overview

Journal Nat Struct Biol

Specialty Cell Biology

Date 2001 Aug 29

PMID 11524674

Citations 111

Authors

P D Zamore

Affiliations

Soon will be listed here.

Abstract

The term RNA interference (RNAi) describes the use of double-stranded RNA to target specific mRNAs for degradation, thereby silencing their expression. RNAi is one manifestation of a broad class of RNA silencing phenomena that are found in plants, animals and fungi. The discovery of RNAi has changed our understanding of how cells guard their genomes, led to the development of new strategies for blocking gene function, and may yet yield RNA-based drugs to treat human disease.

Citing Articles

Gene drive and RNAi technologies: a bio-cultural review of next-generation tools for pest wasp management in New Zealand.

Palmer S, Dearden P, Mercier O, King-Hunt A, Lester P J R Soc N Z. 2024; 52(5):508-525.

PMID: 39440191 PMC: 11485957. DOI: 10.1080/03036758.2021.1985531.

Gene of Chinese White Pine Beetle (): Function and Response to Environmental Treatments.

Wang J, Liao S, Lin H, Wei H, Mao X, Wang Q Int J Mol Sci. 2024; 25(19).

PMID: 39408677 PMC: 11477363. DOI: 10.3390/ijms251910349.

Genome-wide identification and in silico characterization of major RNAi gene families in date palm (Phoenix dactylifera).

Naim D, Ahsan A, Imtiaj A, Mollah N BMC Genom Data. 2024; 25(1):31.

PMID: 38491426 PMC: 10943882. DOI: 10.1186/s12863-024-01217-x.

Fluorescent Nanoparticle-RNAi-Mediated Silencing of Sterol Carrier Protein-2 Gene Expression Suppresses the Growth, Development, and Reproduction of .

Geng K, Zhang Y, Zhao X, Zhang W, Guo X, He L Nanomaterials (Basel). 2023; 13(2).

PMID: 36677998 PMC: 9866532. DOI: 10.3390/nano13020245.

Star Polycation Mediated dsRNA Improves the Efficiency of RNA Interference in .

Wang Z, Li M, Kong Z, Wang E, Zhang B, Lv J Nanomaterials (Basel). 2022; 12(21).

PMID: 36364584 PMC: 9656875. DOI: 10.3390/nano12213809.