Disseminated Intravascular Coagulation and Head Injury

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1975 Jun 1

PMID 1151424

Citations 15

Authors

C J Vecht

C T Sibinga

J M MINDERHOUD

Affiliations

Soon will be listed here.

Abstract

Blood coagulation tests were performed on admission to the hospital and on consecutive days after severe and moderate head injury in 34 patients. Platelet counts and fibrinogen were normal at admission and raised thereafter. The partial thromboplastin time was shortened at admission and lengthened in the following days. Fibrinolytic activity was enhanced at admission. The ethanol gelation test was negative in all patients during the post-traumatic time course. It was concluded that, in the first 24 hours after injury, activated coagulation was present after head injury. In contrast with data of other authors, disseminated intravascular coagulation did not occur in these series.

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References

Gerrits W, Prakke E, van der Meer J, Vreeken J . Causes of a negative ethanol gelation test in diffuse intravascular coagulation. Thromb Diath Haemorrh. 1974; 31(2):299-308. View

Vecht C, Sibinga C . Letter: Head injury and defibrination. Lancet. 1974; 2(7885):905. DOI: 10.1016/s0140-6736(74)91245-8. View

BOWIE E, COOPER H, Fuster V, Kazmier F, OWEN Jr C . The diagnosis of intravascular coagulation. Thromb Diath Haemorrh Suppl. 1973; 56:137-43. View

Kierulf P, GODAL H . Fibrinemia in medical patients screened by the ethanol test. Acta Med Scand. 1971; 190(3):185-90. DOI: 10.1111/j.0954-6820.1971.tb07414.x. View

GODAL H, Abildgaard U . Gelation of soluble fibrin in plasma by ethanol. Scand J Haematol. 1966; 3(5):342-50. DOI: 10.1111/j.1600-0609.1966.tb02378.x. View

Colman R, Robboy S, Minna J . Disseminated intravascular coagulation (DIC): an approach. Am J Med. 1972; 52(5):679-89. DOI: 10.1016/0002-9343(72)90058-7. View

Preston F, Malia R, Sworn M, Timperley W, BLACKBURN E . Disseminated intravascular coagulation as a consequence of cerebral damage. J Neurol Neurosurg Psychiatry. 1974; 37(3):241-8. PMC: 494635. DOI: 10.1136/jnnp.37.3.241. View

Innes D, SEVITT S . COAGULATION AND FIBRINOLYSIS IN INJURED PATIENTS. J Clin Pathol. 1964; 17:1-13. PMC: 480663. DOI: 10.1136/jcp.17.1.1. View

Hardisty R, MACPHERSON J . A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma. Thromb Diath Haemorrh. 1962; 7:215-28. View

10.

Vermylen C, Verstraete M . Antithrombin V: Critical evaluation of its assessment and properties. Thromb Diath Haemorrh. 1960; 5:267-84. View

11.

PROCTOR R, RAPAPORT S . The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. Am J Clin Pathol. 1961; 36:212-9. DOI: 10.1093/ajcp/36.3.212. View

12.

Stormorken H . The preparation of proaccelerin deficient (parahemophilia) plasma for the assay of proaccelerin. Scand J Clin Lab Invest. 1957; 9(3):273-6. DOI: 10.3109/00365515709079970. View

13.

Leclerc M, Khodabandeh A . [Micro method for the determination of plasma fibrinogen]. Ann Biol Clin (Paris). 1953; 11(10-12):596-8. View

14.

SEAMAN A . The recognition of intravascular clotting. The plasma protamine paracoagulation test. Arch Intern Med. 1970; 125(6):1016-21. View

15.

van Doorm J, Huisjes H, Smit Sibinga C . Abruptio placentae, disseminated intravascular coagulation and the use of heparin: a must?. Bibl Anat. 1973; 12:16-21. View

16.

Goodnight S, Kenoyer G, RAPAPORT S, PATCH M, Lee J, Kurze T . Defibrination after brain-tissue destruction: A serious complication of head injury. N Engl J Med. 1974; 290(19):1043-7. DOI: 10.1056/NEJM197405092901903. View

17.

Keimowitz R, Annis B . Disseminated intravascular coagulation associated with massive brain injury. J Neurosurg. 1973; 39(2):178-80. DOI: 10.3171/jns.1973.39.2.0178. View

18.

MERSKEY C, Kleiner G, Johnson A . Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966; 28(1):1-18. View